Two-sample binary phase 2 trials with low type I error and low sample size
نویسندگان
چکیده
منابع مشابه
A two-stage Bayesian design with sample size reestimation and subgroup analysis for phase II binary response trials.
Frequentist sample size determination for binary outcome data in a two-arm clinical trial requires initial guesses of the event probabilities for the two treatments. Misspecification of these event rates may lead to a poor estimate of the necessary sample size. In contrast, the Bayesian approach that considers the treatment effect to be random variable having some distribution may offer a bette...
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ژورنال
عنوان ژورنال: Statistics in Medicine
سال: 2017
ISSN: 0277-6715
DOI: 10.1002/sim.7226